Utilization of Immunohistochemistry in Gynecologic Pathology: An Experience at a Tertiary Care Hospital, Lahore-Pakistan

Background: Immunohistochemistry is an adjunct tool in Surgical Pathology. The fast growing use of immunohistochemistry gynecologic Pathology has revolutionized the fields tumor diagnostics & research. Objective: objective study was to share discuss experience utility Gynecologic Pathology, at a tertiary care hospital Lahore, Pakistan. Patients Methods: This retrospective, descriptive, cross sectional study, carried out Department Fatima Jinnah Medical University, Lahore. All cases which were diagnosed after application during period from 1st July 2019 31st December 2020 included study. Data age patient, marital status, parity, clinical radiological presentation, histopathological findings differentials, list immunohistochemical markers applied case with results final diagnosis. analyzed using SPSS version 17. Results: A total 196 patients ranged 14 years 82 mean 41 ± 7 years. commonest for histological classification tumors female genital tract, identifying precancerous lesions, differentiating primary metastatic CA predicting response chemotherapy via proliferative index Ki67. most commonly used CK, CK7, CK20, CD 3, CD20, ER, PR, VIMENTIN, WT 1, Ki67, 117, SMA, INHIBIN, p53 p63. Practical implication shares common different pathology, highlighting discussing panels scenarios, other pathologists may benefit. Conclusion: important ancillary evaluation pathology cases. However, it cannot replace conventional histopathology. It should always be as histopathology, proper context. Keywords: immunohistochemistry, ovarian carcinoma, leiomyoma, dysgerminoma,